|1983 - 1987||PhD studies at EMBL, Heidelberg, Germany|
|1988 - 1993||Postdoctoral fellow at UCSF, San Francisco, USA|
|1993 - 2001||Group leader at the Institute of Molecular Pathology (IMP), Vienna, Austria|
|2002 - 2008||Senior Scientist at IMP, Vienna, Austria|
|Since 2008||Director at Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany|
You are here
Deregulation of most heterochromatin core components has been linked to complex human disorders that display a strong epigenetic contribution. We will reconstruct heterochromatin by insertion of repeat elements into inert genomic regions. In addition, the transcriptional response of repeat-rich heterochromatin by epigenetic inhibition of chromatin-modifying enzymes will be investigated. Together, these approaches will provide new insights into the genome-wide profile and adaptability of mammalian heterochromatin, as it will be relevant for normal and perturbed development.