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Thomas Jenuwein

1983 - 1987 PhD studies at EMBL, Heidelberg, Germany
1988 - 1993 Postdoctoral fellow at UCSF, San Francisco, USA
1993 - 2001 Group leader at the Institute of Molecular Pathology (IMP), Vienna, Austria
2002 - 2008 Senior Scientist at IMP, Vienna, Austria
Since 2008 Director at Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

A01 The basic composition of mammalian heterochromatin

Deregulation of most heterochromatin core components has been linked to complex human disorders that display a strong epigenetic contribution. We will reconstruct heterochromatin by insertion of repeat elements into inert genomic regions. In addition, the transcriptional response of repeat-rich heterochromatin by epigenetic inhibition of chromatin-modifying enzymes will be investigated. Together, these approaches will provide new insights into the genome-wide profile and adaptability of mammalian heterochromatin, as it will be relevant for normal and perturbed development.

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