A molecular understanding of disease mechanisms requires a global approach to the study of chromatin states and gene regulation. We will provide our infrastructure and expertise with deep-sequencing technologies to generate genome-wide maps of epigenetic modifications in various cell types. A dedicated data management centre will be developed to facilitate access, visualization and routine analysis of genome-wide data. Our group will also offer regular training and help to improve the capacity for epigenetic research towards the development of potential epigenetic therapies.