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C05 Functional role of epigenetic changes in juvenile myelomonocytic leukaemia-initiating cells

Juvenile myelomonocytic leukaemia (JMML) is a malignant myeloproliferative disorder of early childhood. We established a xenotransplantation model of JMML and investigated the stability of epigenetic profiles in JMML-initiating cells. We will focus on the functional role of epigenetics for the leukaemia-initiating activity of JMML cells.

Christian Flotho

1990 - 1996 Study of Medicine, Universities of Freiburg (Germany) and Granada (Spain)
1997 MD thesis, University Children’s Hospital, University Freiburg Medical Centre
1998 - 2003 Resident, Paediatrics, University Freiburg Medical Centre
2003 Board certification “Paediatrics”
2007 Board certification “Paediatric haematology-oncology”
2003 - 2005

Felix Krombholz

2007 - 2012 Study of Biology, Johannes Gutenberg University Mainz
2011 - 2012 Diploma thesis at the Institute of Molecular Genetics, Johannes Gutenberg University Mainz
2012 - present PhD student in the Lab of Dr. med. Christian Flotho, Department of Paediatric Haematology-Oncology, Children's Hospital, University Medical Centre Freiburg
2013 - 2015 Students speaker of the IRTG
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