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B01

Milica Tosic

2008 - 2012 Bachelor of Science in Biology - Faculty of Biology, University of Belgrade, Serbia
2011 - 2013 Master of Science in Biology – Faculty of Biology, University of Belgrade, Serbia
2014 - present PhD student in the Lab of Prof. Dr. Roland Schüle, Centre for Clinical Research, University Freiburg Medical Centre

Publications

Josefina Castex

2005 - 2010 Bachelor in Dental Sc., Los Andes University, Chile
2011 - 2013 Master in Dental Sc. – Master in Biomedical Sc., KU Leuven, Belgium
2014 - 2017 PhD student in the Lab of Prof. Dr. Roland Schüle, Centre for Clinical Research, University Freiburg Medical Centre
2017 PhD thesis, Albert-Ludwigs-University of Freiburg

Publications

B01 The epigenetic regulator LSD1 controls tumourigenesis

The lysine specific demethylase 1 (LSD1) is a key regulator of androgen receptor (AR) function. We have explored the therapeutic potential of lysine-specific demethylase 1 (LSD1) in tumorigenesis. We unravelled that methylation of LSD1 by the histone methyltransferase G9a drives AR-dependent transcription and genomic integrity in prostate cancer. We will use our structural information to design and characterise chemical probes that inhibit binding of chromodomain-helicase-DNA binding protein 1 (CHD1) to methylated LSD1.

Roland Schüle

1977 - 1980 Study of Chemistry, University of Kiel
1980 - 1985 Study of Biochemistry, University of Tübingen
1985 - 1988 PhD work in Genetics and Biochemistry, Max Planck Institute for Biochemistry, Martinsried
1988 - 1991 Postdoctoral fellow at the Salk Institute, La Jolla, USA
1991 - 1993 Group Leader, Preclinical Research Sandoz Ltd, Basel, Switzerland
1993 - 1999
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