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C02

C02 Modulation of microglial enhancer landscapes by host microbiota during health and neurodegeneration

Microglia are macrophages of the central nervous system that modulate the pathology of neurodegenerative diseases such as Alzheimer’s. Recent reports suggest that microorganisms are a critical source of epigenomic changes in myeloid cells. We will investigate regulatory networks controlling chromatin specifications in microglia. The effect of bacteria-derived metabolites will be analysed in a mouse model of Alzheimer’s disease and the microglial chromatin landscape in Alzheimer’s disease will be examined in tissue samples from patients.

Marco Prinz

1990 - 1996 Study of Medicine, Humboldt-University (Charité) Berlin, Germany
1992 - 1994 MD thesis work in Neuroanatomy, Humboldt-University (Charité) Berlin, Germany
1996 - 1997 Medical doctor (AiP) at the Department of Neurology at Charité, Berlin, Germany
1997 - 1998 Postdoctoral fellow at the Max Delbrück Center (MDC) Berlin, Cellular Neurosciences
1999 - 2000

Moumita Datta

2004 Bachelor of Science (B.Sc.) in Chemistry, University of Calcutta, India
2006 Master of Science (M.Sc.) in Biochemistry, University of Calcutta, India
2006 - 2007 Post M.Sc. Associateship at Saha Institute of Nuclear Physics, Kolkata, India
2007 - 2011 Research work at Saha Institute of Nuclear Physics, Kolkata, India
2011 - present
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