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B02 Epigenetic effects of transcription factor NF-E2 in myeloproliferative neoplasms

Myeloproliferative Neoplasms (MPNs) constitute haematologic malignancies for which no curative targeted therapies are available. Epigenetic alterations and elevated activity of the transcription factor NFE2 contribute significantly to the pathophysiology of MPNs. We have identified several epigenetic regulators as novel NFE2 target genes. To generate better tools for the identification of targeted therapies we established two novel MPN mouse models.

Heike Pahl

1985 - 1987 Study of Biochemistry, Wellesley College, Wellesley, USA
1987 - 1992 Study of Genetics, Harvard University / Harvard Medical School, Cambridge, USA
1987 - 1992 PhD work in Genetics, Harvard Medical School, Cambridge, USA
1992 - 1995 Postdoctoral Fellow, Gene Center, LMU Munich and University of Freiburg
1995 - 1997
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