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A06

Ritwick Sawarkar

2001 BSc (Microbiology), Bombay University, Mumbai, India
2004 MSc (Biological Sciences), Indian Institute of Science, Bangalore, India
2004 - 2010 PhD work in Biology, Indian Institute of Science, Bangalore, India
2009 - 2014 Postdoctoral Fellow at ETH, Zurich, Switzerland
2014 - present Group Leader, Max Planck Institute of Immunobiology and Epigenetics Freiburg

A06 Targeting the stability of chromatin factors driving leukaemia

Inhibitors of several epigenetic regulators are potent in treating leukaemia. Our work has shown that the molecular chaperone Heat-shock protein 90 (Hsp90) binds chromatin and stabilises key chromatin factors including the Mixed Lineage Leukaemia protein. We hypothesise that destabilising epigenetic regulators by inhibiting Hsp90 will be beneficial in controlling leukaemia. We shall identify the oncogenic network of proteins stabilised by Hsp90 at chromatin and define the genome-wide location of Hsp90 binding in leukaemic cells.

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